Neurotoxicity of penicillin

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Penicillin

By SIR ALEXANDER FLEMING, F.R.C.S., F.R.C.P., F.R.S. from the Inoculation Department, St. Mary's Hospital I HAVE in the last few years received a certain number of honours, but none has touched me more than the invitation to deliver the Robert Campbell Oration for thtis year in Belfast. I did not know Robert Campbell personally, but I have read much about him and have appreciated my great misfo...

SERUM PENICILLIN LEVEL A FTER INTRAMUSCULA R INJECTION OF 1,200,000 UNITS OF BENZATHINE PENICILLIN G IN CHILDREN WITH RHEUMATIC FEVER

The most accepted method of secondary prophylaxis in rheumatic fever (RF) has been an injection of 1,200,000 units of benzathine penicillin G (BPG) every 4 weeks, but recurrences have been reported in some patients despite such a prophylaxis program. The WHO recommended BPG injections every 3 weeks in high risk patients and situations due to some published data in favor of inadequacy of on...

Penicillin. Iii. the Stability of Penicillin in Aqueous

The instability of penicillin in aqueous solution has been known since the time of its discovery by Fleming (1929). However, beyond the general recognition that excess acidity or alkalinity caused rapid inactivation, little work has been reported on the inactivation of penicillin over a wide pH range and at different temperatures. The maximum stability range of a barium salt of penicillin teste...

Properties of a Penicillin Inactivator Extracted from Penicillin-resistant Staphylococci.